Relationship of Serum Vitamin D with Liver Disease Severity and Bone Abnormalities in Cholestatic Children
| Autor: | Germana Emerita V. Gregorio, Evangeline P. Capul, Jarold P. Pauig |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Acta Medica Philippina. |
| ISSN: | 2094-9278 0001-6071 |
| DOI: | 10.47895/amp.vi0.3148 |
| Popis: | Background. Vitamin D deficiency occurs in 10% to 36% of children with cholestasis. The relationship between serum vitamin D levels, severity of liver disease and bone abnormalities in children has not been extensively investigated. Objective. To determine serum vitamin D levels and its association with liver disease severity and presence of radiographic rickets in children with cholestasis. Methodology. Children aged 0–10 years with cholestasis underwent serum 25-hydroxyvitamin D levels (25-[OH]D) determination, radiographs of wrists and knees and liver function tests. Liver disease severity was evaluated using the Child-Pugh score. Radiographs were assessed using Thacher Rickets Severity Score. Data were analyzed using odds ratio and Spearman’s correlation coefficient. Results. We included 51 children [Mean (SD) age: 5 (6) months, 63% are males], mostly with biliary atresia (51%). Forty-seven (92%) had serum 25-(OH)D deficiency and four (8%) had insufficiency. Radiologic bone abnormalities were observed in 22 (43%) cases; specifically, rickets in 16 (31%). No association was observed with vitamin D levels and liver disease severity (OR 1.27, 95% CI 0.12–13.31) nor with rickets score (OR 0.07, 95% CI 0.004–1.37). Conclusion. Majority of the children with cholestasis had vitamin D deficiency, with a third having radiographic findings of rickets. Serum vitamin D levels were not associated with liver disease severity or with rickets score. |
| Databáze: | OpenAIRE |
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