Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation
| Autor: | Abolghasem Jouyban, Fleming Martínez, William E. Acree, Ana María Cruz-González, María Á. Peña, Martha Sofía Vargas-Santana, Claudia Patricia Ortiz, Daniel Ricardo Delgado |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Sulfamerazine
Solvation Thermodynamics Condensed Matter Physics Mole fraction Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Materials Chemistry medicine Physical and Theoretical Chemistry Solubility Ethylene glycol Dissolution Spectroscopy medicine.drug |
| Zdroj: | Journal of Molecular Liquids. 337:116330 |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2021.116330 |
| Popis: | The equilibrium solubility of sulfamerazine (SMR) in neat ethylene glycol (EG) and nineteen {(EG) (1) + water (2)} mixtures is reported at temperatures from (278.15 to 318.15) K. Mole fraction solubility of SMR (x3) increases with temperature arising and also increases with the EG proportion increasing. It varies from 1.71 × 10−5 in neat water to 7.78 × 10−4 in neat EG at 298.15 K. Solubility behavior was correlated by the extended log-linear model of Yalkowsky, the Jouyban-Acree model, and Jouyban-Acree-van’t Hoff model and the obtained mean percentage deviations are 80.1%, 6.7% and 6.6%, respectively. From the variation of solubility with temperature, the apparent thermodynamic analysis of dissolution and mixing processes was performed in all the mixtures and neat solvents. From inverse Kirkwood-Buff integrals (IKBI) calculations is observed that SMR exhibits low negative preferential solvation parameters by EG in water-rich mixtures. Otherwise, SMR is preferentially solvated by EG in the interval (0.24 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect