Cortical and subcortical processing of speech in cochlear implant recipients with Auditory Neuropathy Spectrum Disorder
| Autor: | Adel Abdel Maksoud Nassar, Tayseer Taha Abdel Rahman, Dalia Mohammed Hassan, Amal Younis |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | QJM: An International Journal of Medicine. 114 |
| ISSN: | 1460-2393 1460-2725 |
| DOI: | 10.1093/qjmed/hcab094.005 |
| Popis: | Background Cochlear implantation (CI) is now recognized as one of the possible lines of interventions in ANSD patients to improve their hearing and speech communication. Desynchronized of the auditory information is the most widely accepted mechanism in ANSD. Objectives To study speech processing in the brainstem level as measured by speech-auditory brainstem response (S-ABR) in ANSD and CAEP P1 in ANSD subjects fitted with CIs and the results will be compared to SNHL subjects fitted with unilateral CIs. Subjects and method A total number of 45 subjects were included classified into three groups (one control and two study groups). The control group 16 subjects, age ranged from 5 to 29.5 years with mean of (11.1 years) with normal peripheral hearing sensitivity. The study group comprised 29 children who underwent cochlear implantation. It was subdivided into two subgroups: Group (SNHL) ;their age ranged from2.9 to 15.5 years with mean of (7.7 years) and group (ANSD); Their age ranged from 3.2 to 29 years with mean of (9.3 years) They were subjected to detailed history taking, aided warble-tone sound field audiometry, Questionnaire and Speech-evoked potentials (P1 &c-ABR) recording evoked by the 150-ms synthesized /da/ syllable stimulus. Results C-ABR waves were detected in 100% of control group, 75% of SNHL group and 53.8% of ANSD group. A statistically significant differences existed between the control group and the two study subgroups regarding the P1 latencies. While; there were no statistically significant differences between {SNHL group &ANSD}. Sound-field S-ABR in the CI recipients showed delayed latencies in both SNHL group &ANSD group comparable to the control group with more delay in ANSD group than SNHL group. Finally, the neural phase locking was significantly higher in CI recipients due to electrical artifact. Conclusions • There were no statistically significant differences between {SNHL group & ANSD group} regarding P1 latency. • C-ABR waves were detected in 75% of SNHL group and 53.8% of ANSD group with delayed latencies and higher amplitude than control group with more delay in ANSD group than SNHL group. The findings of sound-field S-ABR demonstrated that CI recipients have neural encoding deficits in temporal and spectral domains at the brainstem level; therefore, the sound-field S-ABR can be considered an efficient clinical procedure to assess the speech processing in ANSD subjects fitted with cochlear implant. |
| Databáze: | OpenAIRE |
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