| Autor: |
John F. Greene, Punit Kaur, Samuel N. Forjuoh, Glen R. Couchman, Alexzander Asea, Michael D. Reis |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Heat Shock Proteins and Whole Body Physiology ISBN: 9789048133802 |
| DOI: |
10.1007/978-90-481-3381-9_2 |
| Popis: |
Heat shock proteins (HSP) play an important role in human health and physiology and are known to function intracellularly as cytoprotection proteins by protecting cells against a wide variety of stressors, and extracellularly as chaperokines by stimulating the synthesis of pro-inflammatory cytokines, chemokines, and upregulates co-stimulatory molecule expression on antigen presenting cells, and enhancing natural killer (NK) cell-mediated migration and general anti-tumor responses. Obesity is known to be associated with raised serum inflammatory markers suggesting a state of heightened immune activation. The recent findings that antibody titers to several HSP are elevated in dyslipidaemic patients and individuals with established vascular disease, and that patients with Type 2 diabetes have reduced gene expression of Hsp72 which correlates with reduced insulin sensitivity point to an important role for HSP in obesity and Type 2 diabetes. This chapter briefly reviews recent advances in our understanding of the role of Hsp70 in obesity and Type 2 diabetes |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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