Synthesis and Antiviral Evaluation of (-)-3′-Methylcarbovir, (-)-3′-Methylabacavir, and Modified Purine Analogues

Autor:	Erik De Clercq, Honoré Monti, Christophe Pannecouque, Paul Brémond, Gérard Audran
Rok vydání:	2008
Předmět:	Purine chemistry.chemical_compound Enantiopure drug chemistry Stereochemistry Organic Chemistry Purine analogue Catalysis Derivative (chemistry) Nucleobase
Zdroj:	Synthesis. 2009:290-296
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0028-1083213
Popis:	Starting from ethyl (1 S,4 R)-4-hydroxy-2-methylcyclopent-2-ene-1-carboxylate,as a common enantiopure building block readily obtained by enzymatickinetic resolution of the corresponding racemic derivative, 3′-methylcarbovir,3′-methylabacavir, and three modified analogues were synthesizedvia the linear construction of the purine heterocycles. These derivativeswere evaluated as potential agents against HIV-1, HIV-2, and otherimportant viral pathogens. None of the new compounds had significantantiviral activity at a concentration of 100 μg˙mL -¹ ,which was the highest concentration tested.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a1e6dd93aabff9df15f2df1d7bd6b4f1 https://doi.org/10.1055/s-0028-1083213 Zobrazit plný text záznamu