POSS-modified PEG adhesives for wound closure
| Autor: | Jianheng Liu, Licheng Zhang, Peifu Tang, Fei Yang, Yazhong Bu, Decheng Wu, Guofei Sun |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
integumentary system Polymers and Plastics Biocompatibility General Chemical Engineering Organic Chemistry 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences In vivo PEG ratio medicine Wound closure Sutured wounds Adhesive Swelling medicine.symptom Composite material 0210 nano-technology Cell adhesion |
| Zdroj: | Chinese Journal of Polymer Science. 35:1231-1242 |
| ISSN: | 1439-6203 0256-7679 |
| DOI: | 10.1007/s10118-017-1958-x |
| Popis: | PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The in vitro cytotoxicity and in vivo inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. Compared with the sutured wounds, the adhesive-treated wounds showed an accelerated healing process in wounded skin model of the Bama miniature pig, demonstrating that the POSS-modified PEG adhesive is a promising candidate for wound closure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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