| Popis: |
One of the major discoveries in stem cell research in the past decade embraces the development of “organs in a dish,” also known as “organoids.” Organoids are three-dimensional cellular structures derived from primary stem cells of different organ-specific cell types which are capable of self-renewal and maintenance of the parental lineages. Researchers have developed in vitro organoid models to mimic in vivo host–microbial interactions and disease. In this review, we focus on the use of gastrointestinal organoids as models of microbial disease and cancer. |
