Coordination of Zn(II), Pd(II) and Pt(II) with ligands derived from diformylpyridine and thiosemicarbazide: Synthesis, structural characterization, DNA/BSA binding properties and molecular docking analysis
| Autor: | Gelson Manzoni de Oliveira, Bernardo A. Iglesias, Francisco Mainardi Martins, Otávio Augusto Chaves, Thiago V. Acunha, Tiago Bessega, Davi F. Back |
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| Rok vydání: | 2019 |
| Předmět: |
Absorption spectroscopy
biology 010405 organic chemistry Ligand Intercalation (chemistry) 010402 general chemistry 01 natural sciences 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound Bipyramid Crystallography chemistry Materials Chemistry biology.protein Physical and Theoretical Chemistry Bovine serum albumin Semicarbazone DNA Macromolecule |
| Zdroj: | Inorganica Chimica Acta. 496:119049 |
| ISSN: | 0020-1693 |
| DOI: | 10.1016/j.ica.2019.119049 |
| Popis: | Synthesis of three novel inorganic complexes (Zn(II), Pd(II), and Pt(II) – [Zn(H2L)](NO3)2, [Pd(L)], and [Pt(L)], respectively) based on 2,6-diformylpyridine-bis-(4-phenyl) thiosemicarbazone (H2L) was obtained under reflux medium, yielded in the range of 67% and 86%. Characterization of each compound was done via X-ray diffraction and spectroscopic methods. Structural analysis revealed the formation of complexes with pentagonal and quadratic bipyramidal geometry. Electronic absorption spectra for the ligand and inorganic complexes exhibited π → π* and n → π* transitions in the UV region, however, [Pd(L)] and [Pt(L)] showed other less energetic bands attributed to ligand-to-metal charge transfer (LMCT). The interaction between each compound and two macromolecules: calf-thymus DNA (CT-DNA) and bovine serum albumin (BSA) was conducted by spectroscopic techniques combined to molecular docking calculation. For CT-DNA interaction, [Zn(H2L)](NO3)2 is the weakest intercalate compound and the increasing order of Kb values follows [Zn(H2L)](NO3)2 |
| Databáze: | OpenAIRE |
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