First Polynuclear Palladium Compounds [(C5H12NO)(PdCl3)]n and [(C10H16NO)2(Pd2Cl6)] with High Antitumor and Radioprotective Activity
| Autor: | O. S. Erofeeva, M. V. Filimonova, T S Podosinnikova, I. A. Efimenko, A.S. Samsonova, N. A. Ivanova, A. V. Churakov, A. S. Filimonov |
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| Rok vydání: | 2020 |
| Předmět: |
Cisplatin
Single exposure Chemistry General Chemical Engineering Lewis lung carcinoma chemistry.chemical_element General Chemistry Pharmacology 010402 general chemistry 010403 inorganic & nuclear chemistry medicine.disease 01 natural sciences 0104 chemical sciences Metastasis Toxicity medicine Survival rate medicine.drug Palladium |
| Zdroj: | Russian Journal of Coordination Chemistry. 46:339-349 |
| ISSN: | 1608-3318 1070-3284 |
| Popis: | Polymeric palladium complexes [(C5H12NO)(PdCl3)]n (I) and [(C10H16NO)2(Pd2Cl6)] (II) were synthesized for the first time and studied by X-ray diffraction. Complexes I and II were found to have moderate toxicity (3rd class of toxicity) and high antitumor and radioprotective activities. Treatment of Lewis lung carcinoma (LLC) with I and II induced statistically significant antitumor and antimetastatic effects exceeding those of cisplatin: the use of I and II retarded the growth of LLC by 60.0%, while cisplatin retarded it by 48.0%. The decrease in the LLC metastasis was 75% upon the action of I, 91.0% in the case of II, and 69.0% for cisplatin. It was shown that II has a clear-cut radioprotective action. On single exposure of mice to a dose of 8.2 Gy, their survival rate was 58.0% versus 4.5% for the control. Fractional exposure to increasing doses (2.5, 3, and 3.5 Gy) resulted in 75.0% survival rate versus 33.0% for the control. |
| Databáze: | OpenAIRE |
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