The effect of quercetin on hepatic differentiation of human adipose-derived mesenchymal stem cells
| Autor: | Z. B. Kvacheva, Sergei Pinchuk, I. D. Volotovski, I. B. Vasilevich |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
biology Cellular differentiation Mesenchymal stem cell Oncostatin M Adipose tissue Cell Biology Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Biochemistry chemistry 030220 oncology & carcinogenesis medicine Hepatic stellate cell biology.protein heterocyclic compounds Hepatocyte growth factor Quercetin Fibroblast medicine.drug |
| Zdroj: | Cell and Tissue Biology. 10:357-364 |
| ISSN: | 1990-5203 1990-519X |
| DOI: | 10.1134/s1990519x16050102 |
| Popis: | Human adipose-derived mesenchymal stem cells (MSCs) can be stimulated to differentiate into hepatic cells. MSC differentiation was induced by fibroblast growth factor-4, hepatocyte growth factor, oncostatin M, and dexamethasone. The influence of quercetin on MSC hepatic differentiation in culture was assayed, and 1 or 10 μmole/L quercetin added into the induction medium enhanced the manifestation of MSC hepatic differentiation. Urea secretion, cytokeratin 19 expression, and α-fetoprotein synthesis were increased. Quercetin modulated CYP1A–cytochrome P450 activity in the differentiated cells. MSCs differentiated in the presence of quercetin exhibited higher viability and resistance to oxidative stress. |
| Databáze: | OpenAIRE |
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