Enniatin production by Fusarium oxysporum in chemically defined media

Autor:	Horst Kleinkauf, Norbert Madry, Rainer Zocher
Rok vydání:	1983
Předmět:	Fusarium Depsipeptide chemistry.chemical_classification biology General Medicine biology.organism_classification Applied Microbiology and Biotechnology Microbiology Amino acid Biochemistry chemistry Valine Fusarium oxysporum Isoleucine Leucine Enniatin Biotechnology
Zdroj:	European Journal of Applied Microbiology and Biotechnology. 17:75-79
ISSN:	1432-0614 0171-1741
DOI:	10.1007/bf00499854
Popis:	Production of the depsipeptide antibiotic enniatin was studied in submerged cultures of Fusarium oxysporum. The influence of various nutritional factors on growth and enniatin production was investigated. Sucrose and glucose were suitable carbon sources, NaNO3 was the best nitrogen source with respect to growth and production. Enniatin yields up to 2.5 g/l were achieved within 4 days of cultivation of a variant obtained after two subsequent mutagenic treatments. Addition of several amino acids to producing cultures enhanced product formation up to 5 g/l. External supply of the branched-chain amino acids, valine, leucine, and isoleucine triggered an increased formation of the corresponding enniatin homologues which contain the amino acid fed as a constituent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a1cbf184015e19f9a170c22bf8df648b https://doi.org/10.1007/bf00499854 Zobrazit plný text záznamu Full text from SpringerLink