Effect of psychotropic drugs on synaptosomal uptake of H3-?-aminobutyric acid and on Na,K-ATPase activity

Autor:	R. N. Glebov, K. S. Raevskii, N. I. Maisov, Yu. G. Sandalov
Rok vydání:	1976
Předmět:	Fluphenazine Stromal cell Chemistry Tetrabenazine Trifluperidol General Medicine Pharmacology Imipramine General Biochemistry Genetics and Molecular Biology Apomorphine medicine Na+/K+-ATPase Clonogenic assay medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 81:55-57
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00800165
Popis:	Neurotropic drugs belonging to various groups (fluphenazine, nonachlazine, trifluperidol fluacizine, imipramine, diazepam, apomorphine fetanyl, diphenylhydantoin) in experiments in vitro showed an inhibitory effect on active transport of γ-aminobutyric acid (GABA) by synaptosomes of the rat cerebral cortex. In most cases a parallel decrease in the activity of synaptosomal Na,K-ATPase was observed. Substances not changing GABA uptake as a rule had no effect on the activity of the enzyme (carbidine and morphine). Some substances inhibiting Na,K-ATPase were ineffective with respect to GABA uptake (azabuperon, tetrabenazine). It is suggested that the drugs tested have at least two possible points of application: Na,K-ATPase and the hypothetical transmembrane carrier of GABA.
Databáze:	OpenAIRE
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