The role of T-regulatory cells in the pathogenesis of psoriasis
| Autor: | V R Khayrutdinov, A F Mikhaylichenko, M S Mukhina, A V Samtsov, E N Imyanitov, A M Ivanov, V R KHAIRUTDINOV, A F MICHAILICHENCO, M A MUKHINA, A V SAMTSOV, E N IMYANITOV, A M IVANOV |
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| Rok vydání: | 2011 |
| Zdroj: | Vestnik dermatologii i venerologii. 87:78-85 |
| ISSN: | 2313-6294 0042-4609 |
| Popis: | T-regulatory cells control the strength and duration of immune response and play an important role in the pathogenesis of psoriasis. The goal of the study was to examine the content of T-regulatory cells in peripheral blood and affected skin of psoriasis patients, the level of FOXP3 mRNA expression in psoriatic skin. Determination of subpopulations of T-regulatory lymphocytes in peripheral blood was performed using flow cytometry. The median level of FOXP3 mRNA expression was determined in biopsies of the skin by PCR in real time. Immunohistochemistry was performed with monoclonal anti- FOXP3 antibodies. Revealed an increase in the relative content of T-regulatory cells in the peripheral blood of patients with psoriasis in the progressive period, compared with healthy people. The level of FOXP3 mRNA expression in psoriatic foci was 3.1 times higher than in healthy individuals. Was noted a 10-fold increase in the number of T-regulatory lymphocytes in the skin of psoriasis patients in the progressive period, compared with skin from healthy donors. |
| Databáze: | OpenAIRE |
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