Receptores ker de células natural killer
| Autor: | Amanda Vansan Marangon, Jeane Eliete Laguila Visentainer, Ana Maria Sell, Cristiane Conceição Chagas Rudnick, Danilo Santana Alessio Franceschi, Gláucia Andréia Soares Guelsin |
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| Rok vydání: | 2008 |
| Předmět: |
Receptor complex
education.field_of_study Innate immune system Population hemic and immune systems chemical and pharmacologic phenomena General Medicine Human leukocyte antigen Biology Inhibitory postsynaptic potential Molecular biology immune system diseases embryonic structures otorhinolaryngologic diseases Allele education Receptor Gene |
| Zdroj: | Ciência, Cuidado e Saúde. 7 |
| ISSN: | 1984-7513 1677-3861 |
| Popis: | NKC (natural killer cells) are a population of lymphocytes that play an essential role in innate immunity. KIR molecules are receptors expressed on the surface of these cells with an inhibitory or activating function that contributes to the regulation of NK cells. The KIR genes are located on chromosome 19q13 at the Leukocyte Receptor Complex, and exhibit high polymorphism. The KIR ligands are HLA class I molecules. NK cell functions are related to the variation of the expression of these molecules on the surface of the target cells – especially infected, allogeneic and tumor cells. The aim of this work was to make a review about KIR receptors. The Pubmed/medline and ScienceDirect online databases were accessed, using receptor, NK and KIR as keywords. KIR molecular structure, nomenclature and classification, gene diversity, allelic and haplotypic variability and its ligands were described. Regulation of KIR genes expression and NK cell function were also presented. |
| Databáze: | OpenAIRE |
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