Urinary excretion of the drug and its main metabolite in man, after the administration of (±)-, (+)- and (-)-ethylamphetamine

Autor:	L. G. Brookes, A. H. Beckett, E. V. B. Shenoy
Rok vydání:	1969
Předmět:	Pharmacology Drug Hydrochloride Metabolite media_common.quotation_subject Pharmaceutical Science Urine Ethylamphetamine Excretion chemistry.chemical_compound chemistry Oral administration medicine Amphetamine medicine.drug media_common
Zdroj:	Journal of Pharmacy and Pharmacology. 21:151S-156S
ISSN:	2042-7158 0022-3573
Popis:	The urinary excretion of ethylamphetamine and its metabolite amphetamine was studied in man after oral administration of (±)-, (+)-, and (-)-ethylamphetamine hydrochloride. The rates of excretion of these amines are dependant on the pH of the urine. At acid values, the (+)-isomer is metabolized faster and to a greater extent than the (-)-isomer, which is excreted mostly unchanged. The effect of alkyl chain length on stereoselective metabolism of N-alkylamphetamines is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a1b73958163e726fcd4208c229a68da6 https://doi.org/10.1111/j.2042-7158.1969.tb08366.x Zobrazit plný text záznamu Plný text