Urinary excretion of the drug and its main metabolite in man, after the administration of (±)-, (+)- and (-)-ethylamphetamine
Autor: | L. G. Brookes, A. H. Beckett, E. V. B. Shenoy |
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Rok vydání: | 1969 |
Předmět: | |
Zdroj: | Journal of Pharmacy and Pharmacology. 21:151S-156S |
ISSN: | 2042-7158 0022-3573 |
Popis: | The urinary excretion of ethylamphetamine and its metabolite amphetamine was studied in man after oral administration of (±)-, (+)-, and (-)-ethylamphetamine hydrochloride. The rates of excretion of these amines are dependant on the pH of the urine. At acid values, the (+)-isomer is metabolized faster and to a greater extent than the (-)-isomer, which is excreted mostly unchanged. The effect of alkyl chain length on stereoselective metabolism of N-alkylamphetamines is discussed. |
Databáze: | OpenAIRE |
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