Pregnancy leads to changes in the brain functional network: a connectome analysis
| Autor: | Xicheng Song, Feng Zhao, Heng Ma, Haizhu Xie, Yinghong Shi, Kaili Che, Fanghui Dong, Yuna Li, Ning Mao, Peiyou Gong, Tongpeng Chu |
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| Rok vydání: | 2021 |
| Předmět: |
False discovery rate
Pregnancy medicine.medical_specialty Obstetrics business.industry Cognitive Neuroscience Neuropsychology Human brain medicine.disease Functional networks Behavioral Neuroscience Psychiatry and Mental health Cellular and Molecular Neuroscience medicine.anatomical_structure Neurology Connectome medicine Radiology Nuclear Medicine and imaging Neurology (clinical) Two sample business Body mass index |
| Zdroj: | Brain Imaging and Behavior. 16:811-819 |
| ISSN: | 1931-7565 1931-7557 |
| DOI: | 10.1007/s11682-021-00561-1 |
| Popis: | Pregnancy leads to long-lasting changes in human brain structure; however, little is known regarding alterations in the topological organization of functional networks. In this study, we investigated the effect of pregnancy on human brain function networks. Resting-state fMRI data was collected from eighteen primiparous mothers and twenty-four nulliparous control women of similar age, education level and body mass index (BMI). The functional brain network and topological properties were calculated by using GRETNA toolbox. The demographic data differences between two groups were computed by the independent two sample t-test. We tested group differences in network metrics’ area under curve (AUC) using non-parametric permutation test of 1,000 permutations and corrected for false discovery rate (FDR). Differences in regional networks between groups were evaluated using non-parametric permutation tests by network-based statistical analysis (NBS). Compared with the nulliparous control women, a hub node changed from left inferior temporal gyrus to right precentral gyrus in primiparous mothers, while primiparous mothers showed enhanced network global efficiency (p = 0.247), enhanced local efficiency (p = 0.410), larger clustering coefficient (p = 0.410), but shorter characteristic path length (p = 0.247), smaller normalized clustering coefficient (p = 0.111), and shorter normalized characteristic path length (p = 0.705). Although both groups of functional networks have small-world property (σ > 1), the σ values of primiparous mothers were decreased significantly. NBS evaluation showed the majority of altered connected sub-network in the primiparous mothers occurred in the bilateral frontal lobe gyrus (p |
| Databáze: | OpenAIRE |
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