A Practical Approach for Enantio- and Diastereocontrol in the Synthesis of 2,3-Disubstituted Succinic Acid Esters: Synthesis of the pan-Notch Inhibitor BMS-906024

Autor:	Yufen Zhao, Ashvinikumar V. Gavai, Saulnier Mark G, Demartino Michael P, Claude A. Quesnelle, Brian E. Fink, Libing Chen, Patrice Gill, David B. Frennesson, Soong-Hoon Kim, Phil S. Baran
Rok vydání:	2016
Předmět:	chemistry.chemical_compound chemistry Succinic acid Stereochemistry Organic Chemistry Intermolecular force Diastereomer Organic chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences
Zdroj:	Synlett. 27:2254-2258
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0035-1561636
Popis:	An oxidative intermolecular enolate heterocoupling reaction was employed for the synthesis of anti-2,3-disubstituted succinic acid mono- and differentially protected diesters. Tactical approaches to access all the diastereomers are discussed. The method was applied to the synthesis of a potent anticancer agent, BMS-906024.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a1ab4c496ef40e73dd1968f7daf87048 https://doi.org/10.1055/s-0035-1561636 Zobrazit plný text záznamu