Synthesis and in vitro acetylcholinesterase inhibitory activity of some 1-substituted analogues of velnacrine
| Autor: | Gregory M. Shutske, Kevin J. Kapples, Francis P. Huger, Gina M. Bores |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Carboxylic Ester Hydrolases biology Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Velnacrine Inhibitory postsynaptic potential Biochemistry Acetylcholinesterase Chemical synthesis In vitro chemistry.chemical_compound Enzyme chemistry Enzyme inhibitor Drug Discovery biology.protein Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:2789-2792 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)80765-4 |
| Popis: | A number of analogues of 9-amino-1,2,3,4-tetrahydro-1-acridinol (velnacrine), with 1-position substituents other than hydroxy, were prepared and evaluated for in vitro acetylcholinesterase inhibition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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