Histopathological Study of the Effect of Antiandrogen, Chlormadinone Acetate(CMA), on Canine Spontaneous Benign Prostatic Hyperplasia(BPH)
| Autor: | Masashi Tagawa, Rie Ikeda, Masanori Murakoshi, Takaharu Nakayama |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class business.industry Hyperplasia Toxicology medicine.disease Antiandrogen Beagle humanities Pathology and Forensic Medicine Steroidal antiandrogen Andrology Chlormadinone acetate chemistry.chemical_compound medicine.anatomical_structure Atrophy Endocrinology chemistry Prostate Internal medicine medicine Benign prostatic hyperplasia (BPH) business health care economics and organizations |
| Zdroj: | Journal of Toxicologic Pathology. 12:167-170 |
| ISSN: | 1881-915X 0914-9198 |
| DOI: | 10.1293/tox.12.167 |
| Popis: | The effect of a synthetic steroidal antiandrogen, chlormadinone acetate (CMA), on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. Male beagle dogs (5-8 years old) were divided into four experimental groups. Group 1 consisted of untreated controls. Groups 2 to 4 received CMA 0.03, 0.1, and 0.3 mg/kg/day, p.o., respectively, for 6 months. In group 1, glandular hyperplasia of the prostate was clearly detected. In groups 2 to 4, CMA produced marked atrophy of the glandular epithelium. In addition, a histopathological study showed that CMA medication for 6 months exerted no effect on the testes except group 4 or on immunoreactive positive cells to LH antibody (pituitary LH cells). Therefore, it is suggested that CMA (0.03 and 0.1 mg/kg) causes regression of spontaneous canine BPH without any histopathological effects on the testes or pituitary LH cells. However, atrophy of seminiferous tubules in testes was found in CMA 0.3 mg/kg/day-treated animals, due apparently to a direct and/or indirect effect on the testes. It is suggested that a marginal antigonadotrophic effect can not be excluded. |
| Databáze: | OpenAIRE |
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