Magnetic nano-amorphous-iron-oxide-based drug delivery system with dual therapeutic mechanisms
| Autor: | Xue-wu Gea, Mo-zhen Wanga, Li-an Wang, Kun Zeng, Shan Lei, Fu-xing Lin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
biology
technology industry and agriculture Iron oxide Nanoparticle macromolecular substances 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences Combinatorial chemistry 0104 chemical sciences HeLa chemistry.chemical_compound chemistry PEG ratio Drug delivery medicine Doxorubicin Physical and Theoretical Chemistry 0210 nano-technology Drug carrier Ethylene glycol medicine.drug |
| Zdroj: | Chinese Journal of Chemical Physics. 33:376-384 |
| ISSN: | 2327-2244 1674-0068 |
| DOI: | 10.1063/1674-0068/cjcp1906123 |
| Popis: | Smart nanoparticles that respond to pathophysiological parameters, such as pH, GSH, and H2O2, have been developed with the huge and urgent demand for the high-efficient drug delivery systems (DDS) for cancer therapy. Herein, cubic poly(ethylene glycol) (PEG)-modified mesoporous amorphous iron oxide (AFe) nanoparticles (AFe-PEG) have been successfully prepared as pH-stimulated drug carriers, which can combine doxorubicin (DOX) with a high loading capacity of 948 mg/g, forming a novel multifunctional AFe-PEG/DOX nanoparticulate DDS. In an acidic microenvironment, the AFe-PEG/DOX nanoparticles will not only release DOX efficiently, but also release Fe ions to catalyze the transformation of H2O2 to OH, acting as fenton reagents. In vitro experimental results proved that the AFe-PEG/DOX nanoparticles can achieve combination of chemotherapeutic (CTT) and chemodynamic therapeutic (CDT) effects on Hela tumor cells. Furthermore, the intrinsic magnetism of AFe-PEG/DOX makes its cellular internalization efficiency be improved under an external magnetic field. Therefore, this work develops a new and promising magnetically targeted delivery and dual CTT/CDT therapeutic nano-medicine platform based on amorphous iron oxide. |
| Databáze: | OpenAIRE |
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