A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils

Autor: Chien-Yu Fu, Tsung-Pao Wang, Po-Chen Shih, T. H. Punde, Cheng-Hsien Liu, Long Hsu, Hawn-You Chang, Wen-Hao Wu
Rok vydání: 2011
Předmět:
Zdroj: 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference.
DOI: 10.1109/transducers.2011.5969361
Popis: Inflammation is a fundamental biology problem with daily threats to human health. In early inflammatory stage, the most important cell type involved is neutrophil, which represents the most massive leukocyte population. In this paper, we report a 3D reusable microfluidic chip which mimics the capillary endothelial lining and we have made an attempt to imitate the hemodynamic-factor in order to study the extravasation behavior of neutrophils. This microsystem is a continuous flow system which mimics the dynamic, three dimensional micro environment in the blood vessel.
Databáze: OpenAIRE