Carbohydrate-Based Antibiotics: A New Approach to Tackling the Problem of Resistance

Autor:	Thomas K. Ritter, Chi-Huey Wong
Rok vydání:	2001
Předmět:	biology medicine.drug_class Antibiotics General Chemistry Drug resistance Computational biology Proteomics biology.organism_classification Genome Catalysis Antibiotic resistance Biochemistry medicine Identification (biology) Functional genomics Bacteria
Zdroj:	Angewandte Chemie International Edition. 40:3508
ISSN:	1521-3773 1433-7851
DOI:	10.1002/1521-3773(20011001)40:19<3508::aid-anie3508>3.0.co;2-i
Popis:	Recent interest in the problem of antibiotic resistance has led to the identification of new targets and strategies for antibiotic discovery. Among these efforts, the development of small molecules as antibiotics to target carbohydrate receptors or carbohydrate-modifying enzymes represents a new direction. This review covers recent work in this regard and discusses the impact of each strategy on the development of drug resistance. Particularly interesting targets include unique cell-surface carbohydrates, the transglycosylase involved in peptidoglycan biosynthesis, and bacterial RNA. With a greater understanding of the genome of different bacteria as well as advances in functional genomics and proteomics, we can expect the discovery of a variety of targets for the development of novel antibiotics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a181751ca61a0c2f92ed6f0bfea28456 https://doi.org/10.1002/1521-3773(20011001)40:19<3508::aid-anie3508>3.0.co Zobrazit plný text záznamu Plný text