| Popis: |
BackgroundVictims of disasters can develop post-traumatic stress disorder (PTSD) in 30-40% of cases. Application of repetitive transcranial magnetic stimulation (rTMS) shown promising results in PTDS. Transcranial direct current stimulation (tDCS) similar to rTMS, which is a neuromodulation technique, has shown promise in treatment of neuropsychiatric disorders.MethodA clinical trial conducted from March/2015-July-2016 in “KISS nightclub fire” disaster patients diagnosed with PTSD without complete remission of symptoms, over 18-years and who maintained pharmacological treatment. Electrodes positioned as cathode (right DLPFC) and extra-cephalic anode (contralateral deltoid muscle.) A current of 2mA used for 25cm² area (0.08mA/cm² current density) 30min once a day, for 10 continuous days. Patients were assessed pre-intervention, post-intervention, 30-days’ and 90-days’ post-intervention. PTSD Checklist-Civilian version (PCL-C); Montreal Cognitive Assessment (MoCA); Hamilton Depression and Anxiety Rating Scale (HAM-D and HAM-A) were used.Results145 subjects were initially screened and eight analysed. 87,5% were female. 30.88±7.74 years were the mean age (ranging 23-44). post-intervention results demonstrate: no cognitive impairment (MoCA); 60% reduction in HAM-D scale (patients diagnose as moderate depression turns normal diagnosis) (p |
