| Autor: |
Priyanka Singh, Manoj Kumar Singh, Ravindra K. Gupta, Vigneshwar Senthivel, Neha Jha, Namita Soni, Rahul C. Bhoyar, Swapnil Mishra, Debasis Dash, Shantanu Sengupta, Ranjeet Maurya, VR Arvinden, Uma Sharma, Hemlata Lall, Pooja Sharma, Mercy Rophina, Sujeet Kumar Singh, Thomas A. Mellan, Priyanka Mehta, Sandhya Kabra, Lipi Thukral, Preeti Madan, Rajesh Pandey, Viren Sardana, Nitin Batheja, Seth Flaxman, Partha Rakshit, Saman Fatihi, Robin Marwal, Samir Bhatt, Mohit Kumar Divakar, Rajat Ujjainiya, Mohamed Imran, Bani Jolly, Kalaiarasan Ponnusamy, Mahesh Shanker Dhar, Mohammed Faruq, Charles Whittaker, A Vivekanand, Meena Datta, V. S. Radhakrishnan, Urmila Chaudhary, Himanshu Chauhan, Sanket Kulkarni, Salwa Naushin, Anurag Agrawal, Hema Gogia |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.06.02.21258076 |
| Popis: |
In April 2021, after successfully enduring three waves of the SARS-CoV2 pandemic in 2020, and having reached population seropositivity of about 50%, Delhi, the national capital of India was overwhelmed by the fourth wave. Here, we trace viral, host, and social factors contributing to the scale and exponent of the fourth wave, when compared to preceding waves, in an epidemiological context. Genomic surveillance data from Delhi and surrounding states shows an early phase of the upsurge driven by the entry of the more transmissible B.1.1.7 variant of concern (VOC) into the region in January, with at least one B.1.1.7 super spreader event in February 2021, relatable to known mass gatherings over this period. This was followed by seeding of the B.1.617 VOC, which too is highly transmissible, with rapid expansion of B.1.617.2 sub-lineage outpacing all other lineages. This unprecedented growth of cases occurred in the background of high seropositivity, but with low median neutralizing antibody levels, in a serially sampled cohort. Vaccination breakthrough cases over this period were noted, disproportionately related to VOC in sequenced cases, but usually mild. We find that this surge of SARS-CoV2 infections in Delhi is best explained by the introduction of a new highly transmissible VOC, B.1.617.2, with likely immune-evasion properties; insufficient neutralizing immunity, despite high seropositivity; and social behavior that promoted transmission. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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