Adjuvant chemotherapy for invasive nonmetastatic breast cancer in limited-resource countries: Evidence-based guidelines therapies versus allocation of resources matter

Autor:	Maria Teresa Bustamante-Teixeira, M. R. Guerra, J. R. Duarte-Cintra, C. Domenge
Rok vydání:	2008
Předmět:	Oncology Cancer Research medicine.medical_specialty Cyclophosphamide Anthracycline Proportional hazards model business.industry medicine.medical_treatment Disease medicine.disease Chemotherapy regimen Breast cancer Internal medicine medicine Methotrexate business Adjuvant medicine.drug
Zdroj:	Journal of Clinical Oncology. 26:11523-11523
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2008.26.15_suppl.11523
Popis:	11523 Background: In the last decades, the use of adjuvant systemic treatment for early breast cancer has increased progressively and has contributed to the disease survival improvement. Cyclophosphamide, methotrexate and 5-fluorouracil (CMF) combination was among the first adjuvant chemotherapy schemes found to decrease both disease recurrence and mortality. Then several studies have suggested that anthracycline-based regimens are more effective than others. However, treating breast cancer under the restriction of significantly limited health care resources poses a great challenge. Methods: We analyzed the 5-year breast cancer specific survival (BCSS) among 428 women diagnosed with invasive nonmetastatic disease between 1998 and 2000, who underwent curative surgery and adjuvant chemotherapy in the Southeast Brazilian region, to compare outcome according to the type of chemotherapy regimen used (CMF versus anthracycline). Kaplan-Meier method and Cox proportional hazard model were used to calculate BCSS an...
Databáze:	OpenAIRE
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