Meta-analysis of the Effects of Paclitaxel-Eluting Stents Versus Bare Metal Stents on Volumetric Intravascular Ultrasound in Patients With Versus Without Diabetes Mellitus††Conflict of interest: Drs. Weissman, Dawkins, Grube, Ellis, and Cannon have received research grants from Boston Scientific Corporation. Drs. Mintz, Ellis, and Cannon are on the speaker's bureau of and have received honoraria from Boston Scientific Corporation. Drs. Ellis, Cannon, and Stone are consultants for and are on the advisory board of Boston Scientific Corporation. Drs. Mandinov and Baim have ownership interest or stock in and are employed at Boston Scientific Corporation
| Autor: | Stephen G. Ellis, Neil J. Weissman, Louis Cannon, Keith D. Dawkins, Zaki Masud, Gregg W. Stone, Donald S. Baim, Gary S. Mintz, Masashi Kimura, Eberhard Grube, Lazar Mandinov |
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| Rok vydání: | 2008 |
| Předmět: |
Neointima
medicine.medical_specialty Intimal hyperplasia medicine.diagnostic_test business.industry medicine.medical_treatment Ultrasound Urology Stent equipment and supplies medicine.disease Surgery surgical procedures operative Restenosis Drug-eluting stent Internal medicine Diabetes mellitus Intravascular ultrasound medicine Cardiology cardiovascular diseases Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American Journal of Cardiology. 101:1263-1268 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2007.12.025 |
| Popis: | Diabetes mellitus is a strong predictor of in-stent restenosis after bare-metal stent placement because of exaggerated intimal hyperplasia (IH). In this study, serial intravascular ultrasound was used to evaluate the effects of polymer-based, paclitaxel-eluting stents (PES) on in-stent neointima formation in patients with and without diabetes. A volumetric IVUS meta-analysis of 956 patients randomized to PES or bare-metal stents in the TAXUS IV (n = 268), TAXUS V (n = 509), and TAXUS VI (n = 179) trials was performed. Diabetes was present in 273 of the 956 patients (28.6%). Stent, luminal, and IH areas were measured every millimeter within the stent, and volumes, percentage IH (%IH), and neointima-free stent length were calculated. Patients with diabetes treated with bare-metal stents had greater IH volumes (78.9 vs 61.2 mm 3 , p = 0.0095) and %IH (34.9% vs 30.1%, p = 0.0186) compared with those without diabetes. However, patients with diabetes treated with PES had similar median IH volume (22.8 vs 16.3 mm 3 , p = 0.35) and median %IH (9.1% vs 9.2%, p = 0.27) compared with those without diabetes and significantly less IH volume and %IH than after bare-metal stent implantation (p |
| Databáze: | OpenAIRE |
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