EFFECT OF ALCOHOL INTOXICATION AND ACTH ON LIVER ASCORBIC ACID IN THE GUINEA PIG12

Autor:	G. M. Duncan, J. C. Forbes
Rok vydání:	1954
Předmět:	medicine.medical_specialty Ethanol business.industry Cholesterol Alcohol Adrenocorticotropic hormone Scurvy medicine.disease Ascorbic acid Guinea pig chemistry.chemical_compound Endocrinology Alcohol intoxication chemistry Internal medicine Medicine business
Zdroj:	Endocrinology. 55:822-827
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-55-6-822
Popis:	THE administration of an intoxicating amount of alcohol to intact rats (Forbes and Duncan, 1951; Smith, 1951) and guinea pigs (Forbes and Duncan, 1951) has been shown to cause a reduction in the concentration of ascorbic acid and cholesterol in the adrenal glands. This adrenal response does not occur in hypophysectomized rats (Forbes and Duncan, 1951; Smith, 1951). However, in spite of this effect of alcohol on the adrenal ascorbic acid, repeated moderate alcohol intoxication in guinea pigs maintained with a scorbutogenic diet did not appear to hasten the rate of development of scurvy (Forbes and Duncan, 1953). Mortality rate and adrenal cholesterol concentration both were quite comparable to those found in pair-fed controls. It would thus seem that the ascorbic acid that left the adrenals as a result of alcohol intoxication could not have been entirely lost to the body, but may have migrated to some other tissue or organ.
Databáze:	OpenAIRE
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