| Autor: |
Dennis E. Jewell, Selena K. Tavener, Regina L. Hollar, Kiran S. Panickar |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Metabolomics. 18 |
| ISSN: |
1573-3890 |
| DOI: |
10.1007/s11306-022-01925-4 |
| Popis: |
Introduction There is a significant incidence of cats with renal disease (RD) and calcium oxalate (CaOx) kidney uroliths in domesticated cats. Foods which aid in the management of these diseases may be enhanced through understanding the underlying metabolomic changes. Objective Assess the metabolomic profile with a view to identifying metabolomic targets which could aid in the management of renal disease and CaOx uroliths. Method This is a retrospective investigation of 42 cats: 19 healthy kidney controls, 11 with RD, and 12 that formed CaOx nephroliths. Cats were evaluated as adults (2 through 7 years) and at the end of life for plasma metabolomics, body composition, and markers of renal dysfunction. Kidney sections were assessed by Pizzolato stain at the end of life for detection of CaOx crystals. CaOx stone presence was also assessed by analysis of stones removed from the kidney at the end of life. Results There were 791 metabolites identified with 91 having significant (p Conclusions The metabolomic changes show specific metabolites which respond generally to both renal diseases while the metabolomic profile still differentiates cats with RD and cats with CaOx uroliths. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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