Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C–carbonyls
| Autor: | Maxime Munch, Benjamin H. Rotstein, Uzair S. Ismailani, Braeden Mair |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Chemistry Metals and Alloys General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 3. Good health 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Nucleophile Wittig reaction Materials Chemistry Ceramics and Composites Thiocarbamates |
| Zdroj: | Chemical Communications. 57:5266-5269 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/d1cc01016f |
| Popis: | A direct CO2-fixation methodology couples structurally diverse iminophosphoranes with various nucleophiles to synthesize ureas, carbamates, thiocarbamates, and amides, and is amenable for 11C radiolabeling. This methodology is practical, as demonstrated by the synthesis of >35 products and isolation of the molecular imaging radiopharmaceuticals [11C]URB694 and [11C]glibenclamide. |
| Databáze: | OpenAIRE |
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