| Autor: |
Irina Chernokhaeva, Ludmila Archakova, Anna Starshinova, Tatiana Vinogradova, Maria Pavlova, Nadezda Sapozhnikova, Piotr Yablonskii |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
10.2 Tuberculosis. |
| Popis: |
Introduction: In accordance to international classification Tioureidoiminomethylpyridinium perchlorate ( Perchlozon) belongs to thioacetazone group [D.Tomas, 2014] . Objective: to confirm data on safety and efficacy of Tioureidoiminomethylpyridinium perchlorate (Pch) in treatment of multidrug resistant (MDR) lung tuberculosis. Materials and methods: in vitro Pch demonstrated significant inhibiting effect on viability of drug-resistant mycobacteria strains of TB. Wherein MIC of the substance varied from 0.78 to 6.25 ug/ml. In the reported clinical study, which was performed in 2013-2014, 49 patients with MDR lung tuberculosis were enrolled. The patients were divided in two groups: Group 1 (main) 25 patients were administered Pch in addition to 6 other anti-tuberculosis drugs; in Group II (comparison) 24 patients received 6 anti-tuberculosis drugs. Duration of treatment in both groups was 6 months. After that in both groups 5 drugs in 6 mohth. Statistical analysis was peformed using SPSS 16.0. Results and their discussion: In Group 1 the most common adverse drug reactions were endocrine disorders (18.4% (9) vs (0), p Conclusion: Efficacy of treatment with Pch was 88.0% in complex with other anti-tuberculosis drugs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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