One-step preparation of [2,3-3H]1-aminocyclopropanecarboxylic acid: A useful ligand for strychnine-insensitive glycine receptors

Autor:	Phil Skolnick, Pamela Lamb, Piotr Popik, Anita H. Lewin
Rok vydání:	1994
Předmět:	Chemistry Stereochemistry Organic Chemistry Biological activity Ligand (biochemistry) Biochemistry Analytical Chemistry Drug Discovery Glycine Radioligand NMDA receptor Radiology Nuclear Medicine and imaging Tritium Specific activity Glycine receptor Spectroscopy
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 34:1063-1068
ISSN:	0362-4803
DOI:	10.1002/jlcr.2580341109
Popis:	Catalytic hydrogenation of 1-aminocyclopropenecarboxylic acid under tritium gas afforded [2,3-3H]1-aminocyclopropanecarboxylic acid with specific activity 26 Ci/mmol, determined by a combination of 1H and 3H NMR. Pilot radioligand binding assays indicate this compound will be a useful probe for the NMDA receptor-associated strychnine-insensitive glycine receptor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a1552ec3fae5b439b028a52b2f4ee69d https://doi.org/10.1002/jlcr.2580341109 Zobrazit plný text záznamu Plný text