EFFICIANCY OF IMMUNOTHERAPY IN PATIENTS WITH PERSISTENT ALLERGIC RHINITIS
| Autor: | Марина Владимировна Антонюк (Ru), Marina V. Antonyuk, S Suleymanov, Tatyana A. Gvozdenko, Tatyana P. Novgorodtseva |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine medicine.medical_specialty business.industry medicine.medical_treatment Immunotherapy Dermatology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030228 respiratory system Pediatrics Perinatology and Child Health medicine In patient business |
| Zdroj: | Bulletin physiology and pathology of respiration. 1:32-37 |
| ISSN: | 1998-5029 |
| DOI: | 10.12737/article_5c1264ee93f132.73406573 |
| Popis: | The dynamics of parameters of cytokine status in patients with allergic rhinitis in view of efficiency of allergen-specific immunotherapy (ASIT) was studied in this work. 62 subjects with moderate persistent rhinitis at the age of 18-40 years old were included in the study. For specific diagnosis and treatment there we used standard allergens. ASIT was performed by the classical scheme. The concentrations of IL-4, IL-5, IL-6, IL-8 in the blood serum were measured by the enzyme immunoassay. A good or excellent effect of treatment with ASIT was achieved in 62.9% of cases, and satisfactory one in 37.1% of cases. The analysis of the dynamics of IL-4, IL-5, IL-6, IL-8 concentrations showed that the efficiency of ASIT in patients with allergic rhinitis depends on the ability of the immune system to activation by low doses of the allergen, quite fast suppression of proinflammatory cytokines induced by them, and active functioning of the system of anti-inflammatory cytokines. |
| Databáze: | OpenAIRE |
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