G-CSF in the setting of acute myocardial infarction
| Autor: | Christoph A. Nienaber, Michael Petzsch, Stephan Kische, Esther Adolf, Stephan Drawert, Hüseyin Ince, Tilo Kleinfeldt, Tim C. Rehders |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Heart disease business.industry medicine.medical_treatment Bone Marrow Stem Cell Granulocyte medicine.disease Granulocyte colony-stimulating factor medicine.anatomical_structure Cytokine Internal medicine medicine Cardiology Myocyte cardiovascular diseases Myocardial infarction Stem cell Cardiology and Cardiovascular Medicine Intensive care medicine business |
| Zdroj: | European Heart Journal Supplements. 8:H40-H45 |
| ISSN: | 1554-2815 1520-1554 |
| Popis: | Experimental data suggest that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) may have potential as a novel regenerative strategy in the setting of acute myocardial infarction (AMI). Potentially beneficial effects of G-CSF may be attributed mainly to direct action of the cytokine G-CSF on injured myocardium by inhibition of apoptosis, rather than to differentiation of mobilized bone marrow stem cells into cardiac myocytes. This article reviews potential cardioprotective effects of G-CSF and discusses experimental and clinical findings with G-CSF in the setting of AMI. |
| Databáze: | OpenAIRE |
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