| Autor: |
Ossama El-Kabbani, Deborah A. Carper, Michelle H. McGowan, Stephan L. Ginell |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Protein & Peptide Letters. 3:427-434 |
| ISSN: |
0929-8665 |
| Popis: |
Abstract: Aldehyde reductase is an enzyme capable of metabolizing a wide variety of aldehydes to their corresponding alcohols.The X-ray crystal structure of porcine aldehyde reductase holoenzyme has been refined to a crystallographic R-factor of 0.20 at 2.0 A resolution. We have modeled the inhibitor zopolrestat in the active site of porcine aldehyde reductase in order to obtain a picture of the binding conformation of inhibitors to the enzyme. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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