DDAVP responsiveness in children with mild or moderate haemophilia A correlates with age, endogenous FVIII:C level and with haemophilic genotype
| Autor: | M. E. Seary, D. Feldman, Manuel Carcao |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty Pediatrics business.industry Haemophilia A Endogeny Hematology General Medicine Moderate haemophilia A urologic and male genital diseases medicine.disease Gastroenterology Disease severity hemic and lymphatic diseases Internal medicine Genotype medicine Mild haemophilia A Desmopressin business hormones hormone substitutes and hormone antagonists Genetics (clinical) medicine.drug Cohort study |
| Zdroj: | Haemophilia. 18:50-55 |
| ISSN: | 1351-8216 |
| DOI: | 10.1111/j.1365-2516.2011.02572.x |
| Popis: | In most individuals with moderate/mild haemophilia A, FVIII:C levels increase following DDAVP administration to a haemostatic range, thus avoiding the need for FVIII concentrates. We sought to determine the relationship between responsiveness to DDAVP in boys ( 0.15 U mL(-1)). Almost all patients with the same mutation had the same response to DDAVP or only a minor discordance in response. Patient's age, disease severity and genotype all are predictors of response to DDAVP. |
| Databáze: | OpenAIRE |
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