Heterocyclic Aminoboron Compounds as Antituberculosis Agents

Autor:	Alain M. Vallée, Haoxin Li, Stephen A. Westcott, Andreas Decken, Christopher A. Gray, Lachlan S. Campbell-Verduyn, Eric G. Bowes, Christopher M. Vogels
Rok vydání:	2014
Předmět:	inorganic chemicals biology Pinacol medicine.drug_class chemistry.chemical_element General Chemistry biology.organism_classification Antimycobacterial Mycobacterium tuberculosis chemistry.chemical_compound chemistry medicine Organic chemistry Boron Single crystal
Zdroj:	Heteroatom Chemistry. 25:100-106
ISSN:	1042-7163
DOI:	10.1002/hc.21141
Popis:	We have examined six boron compounds for their potential antituberculosis activities. Addition of 2-formylphenyl pinacol boronate ester to tetraamine derivatives gave three new aminoboron compounds, which were elementally pure when obtained, and one example was characterized by a single crystal X-ray diffraction study. Heterocyclic aminoboron compounds 1–4 showed moderate degrees of antimycobacterial activity against Mycobacterium tuberculosis.
Databáze:	OpenAIRE
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