| Autor: |
Shu-Yi Ding, Yin Cheng, Yi-Jie Huang, Xin Gao, Jia-Li Yan, Lin-Qin Wang, Hou-Li Zhao, Rui Wang, Sang-Sang Chen, Tian-Li Teng, Nian Liu, Ming-Ming Zhang, Ai-Yun Jin, Yong-Xian Hu |
| Rok vydání: |
2023 |
| DOI: |
10.21203/rs.3.rs-2528277/v1 |
| Popis: |
Purpose To ascertain the risk factors and prevalence of non-infectious diarrhea among participants with multiple myeloma who treated with chimeric antigen receptor T-cell immunotherapy. Methods This study enrolled 88 patients with multiple myeloma who received chimeric antigen receptor T-cell immunotherapy at one tertiary general hospital in China. Participants were categorized into diarrhea subgroup and non-diarrhea subgroup according to the occurrence of diarrhea. Demographic data and self-reported measurements and planning were obtained from questionnaires and clinical data from hospital databases. Results In total, 50 patients suffered from non-infectious diarrhea, with the prevalence of 56.8%. Multiple logistic regression analysis showed that severe cytokine release syndrome (OR = 5.980), underlying diseases (OR = 4.184), previous treatment lines ≥ 6 (OR = 6.292) were prominent hazardous factors for non-infectious diarrhea (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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