Manufacturing prototypes for paper-based diagnostic devices

Autor: Rachel N. Deraney, Charles R. Mace
Rok vydání: 2013
Předmět:
Zdroj: Microfluidics and Nanofluidics. 16:801-809
ISSN: 1613-4990
1613-4982
DOI: 10.1007/s10404-013-1314-6
Popis: Diagnostic assays created using simple and inexpensive materials have the potential to transform healthcare management systems in resource-limited settings. This change can be caused by making assays more accessible (e.g., by improving portability) or by inspiring the development of tests that do not exist currently but would solve a considerable need. Microfluidic devices produced from patterned paper have emerged as a promising candidate for a general platform capable of supporting the development of these diagnostic assays. The ability to manufacture paper-based diagnostic assays reproducibly and in large volumes—potentially hundreds of millions of devices per year per assay—is a critical component of the successful translation of these tools out of the laboratory and into the hands of users. This subject, however, has been largely overlooked in lieu of efforts to develop new tools and techniques. In this review, we summarize the recent advances in two processes that are required to fabricate paper-based diagnostic assays: patterning microfluidic channels into paper and assembling devices. In addition, we discuss the advantages and disadvantages of each process in the context of scalability and potential use as a method to manufacture point-of-care devices.
Databáze: OpenAIRE
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