Enantioselective copper-catalyzed conjugate addition of diethylzinc to enones using new chiral P,N ligands composed of (S)-2-alkyl-2-aminoethylphosphines and α-substituted pyridines

Autor:	Toshiaki Morimoto, Masato Suzuki, Yoichi Yamaguchi, Akihito Saitoh
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Chalcone Chemistry Ligand Organic Chemistry Enantioselective synthesis Diethylzinc Biochemistry Medicinal chemistry chemistry.chemical_compound Cyclohexenone Drug Discovery Copper catalyzed Alkyl Conjugate
Zdroj:	Tetrahedron Letters. 41:10025-10029
ISSN:	0040-4039
Popis:	New P,N ligands prepared from (S)-2-alkyl-2-aminoethylphosphines and α-substituted pyridines are efficient chiral ligands for the copper-catalyzed conjugate addition of diethylzinc to 2-cyclohexen-1-one and chalcone. The best result (90–91% ee) for the cyclohexenone was obtained with Cu(OTf)2 (0.7–1 mol%) and a P,N ligand 4 derived from (S)-1-(diphenylphosphino)-3-methyl-2-butanamine and 6-methylpyridine-2-carboxaldehyde.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a10eeabbf049b9eb5a86d10a791b18ec https://doi.org/10.1016/s0040-4039(00)01789-5 Zobrazit plný text záznamu Full Text from ScienceDirect