Protective Effect of Lycium barbarum Polysaccharides Against Doxorubicin-induced Testicular Toxicity in Rats
| Autor: | Haiyan Gao, Yunxiang Chen, Guoliang Zhou, Zhenqiang You, Yaoxian Xuan, Jian Yu, Yanfei Xin |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
medicine.medical_specialty Antioxidant biology business.industry medicine.medical_treatment biology.organism_classification medicine.disease_cause Sperm nervous system diseases Immunology Toxicity polycyclic compounds medicine Histopathology Doxorubicin Lycium business Saline Oxidative stress medicine.drug |
| Zdroj: | Phytotherapy Research. 26:716-721 |
| ISSN: | 0951-418X |
| DOI: | 10.1002/ptr.3633 |
| Popis: | The present study aimed to investigate whether Lycium barbarum polysaccharides (LBP) would protect against doxorubicin (DOX)-induced testicular toxicity. Male Sprague-Dawley rats were treated with distilled water (4 mL/kg) or LBP (200 mg/kg, p.o.) daily for 10 days and followed by saline (0.9 %, 10 mL/kg) or DOX (10 mg/kg) intravenous injection at day 7. Pretreatment with LBP ameliorated DOX-induced reduction in the testicular weights, sperm concentrations and percentage of motile sperms, as well as the increase in abnormal sperm rate. LBP administration to DOX-treated rats successfully reversed the changes in MDA and GHS-Px levels. Compared with the control, pretreatment with LBP significantly increased the plasma testosterone level in the LBP + DOX group. The histopathology examinations further confirmed that LBP effectively attenuated DOX-induced severe degenerative changes of seminiferous tubules. This study illustrated the capability of LBP in attenuating testicular oxidative stress and protecting testis-specific toxicity in DOX-exposed rats. Copyright © 2011 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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