Popis: |
Experiments on the biosynthesis of the menadione chromophore of axenomycin D in Streptomyces lisandri resulted in the specific incorporation of label from l -[13C-Me]methionine, [1-13C]propionate, [2,3-13C2]propionate, [3-13C]propionate, [U-13C3]glycerol and [U-13C6]glucose. The data indicate that the menadione chromophore is derived from a metabolite of the shikimate pathway. The mode of incorporation shows, however, that the biosynthesis of the menadione chromophore of axenomycins differs from the biosynthesis of the menadione chromophore of menaquinones. |