Biosynthesis of axenomycin d: Incorporation of 13C-labelled precursors into the menadione chromophore, desoxysugars and the axenolide

Autor: A. Boos, V. Friese, H.-J. Bauch, Eckhard Leistner
Rok vydání: 1993
Předmět:
Zdroj: Phytochemistry. 32:613-622
ISSN: 0031-9422
DOI: 10.1016/s0031-9422(00)95145-8
Popis: Experiments on the biosynthesis of the menadione chromophore of axenomycin D in Streptomyces lisandri resulted in the specific incorporation of label from l -[13C-Me]methionine, [1-13C]propionate, [2,3-13C2]propionate, [3-13C]propionate, [U-13C3]glycerol and [U-13C6]glucose. The data indicate that the menadione chromophore is derived from a metabolite of the shikimate pathway. The mode of incorporation shows, however, that the biosynthesis of the menadione chromophore of axenomycins differs from the biosynthesis of the menadione chromophore of menaquinones.
Databáze: OpenAIRE