One-step in-syringe dispersive liquid–liquid microextraction and GC-FID determination of trace amounts of di(2-ethylhexyl) phthalate and its metabolite in human urine samples
| Autor: | Abdolali Khammari, Mashaallah Rahmani, Masoome Sheikh, Shahnaz Sargazi, Ramazan Mirzaei, Mahdi Mohammadi |
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| Rok vydání: | 2017 |
| Předmět: |
Detection limit
endocrine system Chromatography Trace Amounts Metabolite 010401 analytical chemistry Plasticizer Phthalate Urine 010501 environmental sciences 01 natural sciences 0104 chemical sciences Analytical Chemistry law.invention chemistry.chemical_compound chemistry law Flame ionization detector Gas chromatography 0105 earth and related environmental sciences |
| Zdroj: | Journal of Analytical Chemistry. 72:557-561 |
| ISSN: | 1608-3199 1061-9348 |
| Popis: | Di(2-ethylhexyl) phthalate (DEHP) is used as plasticizer in polyvinylchloride (PVC) plastics. Its metabolites and the parent phthalates are considered toxic. As the DEHP plasticizers are not chemically bound to PVC, they can migrate, evaporate or be leached into indoor air and atmosphere, foodstuff, and other materials. We have reported a novel, easy and available analytical method for the determination of DEHP and its metabolite, mono(2-ethylhexyl) phthalate (MEHP) in human urine samples by the in-syringe dispersive liquid–liquid microextraction method coupled with gas chromatography with flame ionization detector. The limits of detection and precision (RSD) were 2.5 μg/L and 1.4% for DEHP and 1.1 μg/L and 3.0% for MEHP, respectively. This method could be utilized for routine monitoring of the trace DEHP and MEHP in urine of human exposure to plasticizers. |
| Databáze: | OpenAIRE |
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