Effects of Asparagus cochinchinensis (Lour.) Merr. on the Stimulation of Osteoblast Differentiation and Inhibition of Osteoclast Generation
| Autor: | Jong Keun Kim, Si Na Kim, Seung Youn Lee |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Nutrition and Dietetics biology Chemistry Osteoporosis Acid phosphatase food and beverages Stimulation Osteoblast medicine.disease Resorption medicine.anatomical_structure Endocrinology Multinucleate Osteoclast Internal medicine medicine biology.protein Alkaline phosphatase Food Science |
| Zdroj: | Journal of the Korean Society of Food Science and Nutrition. 37:16-19 |
| ISSN: | 1226-3311 |
| DOI: | 10.3746/jkfn.2008.37.1.16 |
| Popis: | Bone mass in adults decreases with age because of the imbalance between the rate of bone formation and resorption. We performed this study to investigate whether Asparagus cochinchinensis (Lour.) Merr. (ACAE) plays a role in osteoblasts differentiation and osteoclasts formation. Ethanol extract of ACAE showed increase in the differentiation and alkaline phosphatase activity of osteoblasts. Also, it decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (OCLs) and TRAP activity. Therefore, ACAE has the potential to prevent bone-related diseases such as osteoporosis by increasing the differentiation of osteoblasts and reducing both the number and activity of osteoclasts. |
| Databáze: | OpenAIRE |
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