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Background:There is a high incidence in the elderly who come down with osteoporotic vertebral compression fracture (OVCF) and percutaneous kyphoplasty (PKP) is an effective solution which can relieve pain quickly. Previous studies have shown that both the volume and the distribution of bone cement filling are related to the clinical outcome after PKP surgery. However, the influence of bone cement leakage through the endplate after PKP on intervertebral disc remains to be explained. Methods:118 patients with single level OVCF operated by PKP were retrospectively reviewed from 2015 to 2020. These patients were grouped according to the degree of bone cement leakage. Group A: Bone cement leakage involving one endplate relative to the intervertebral disc. Group B: Bone cement leakage involving one endplate and the adjacent disc. Group C: Bone cement leakage involving both endplates of the intervertebral disc. The following variables were reviewed: gender, age, BMI, BMD and surgical parameters including cement volume (CV), Oswestry Disability Index (ODI), Visual analogue Scale (VAS), Anterior vertebral height ration (AVHR), Local kyphotic angle (LKA), Intervertebral space height (ISH) and the incidence of complications.Results:Compared with the preoperative for all groups, the VAS, ODI, AVHR, LKA and ISH were improved significantly after PKP. There is no significant difference among groups in AVHR and LKA (P> 0.05). Compared with preoperative levels, there was a significant reduction in fracture perivertebral pain in all groups after the surgery, but at the last follow-up, the VAS of Group C were worser than other groups (3.28±0.29 vs. 2.55±0.67vs. 1.73±0.51, P |