Toxicity of first-line drugs for treatment of tuberculosis in children: review
| Autor: | Stephen M. Graham, Alexis Frydenberg |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Tuberculosis biology business.industry Nausea Incidence (epidemiology) Public Health Environmental and Occupational Health medicine.disease biology.organism_classification Surgery Malnutrition Infectious Diseases Acquired immunodeficiency syndrome (AIDS) medicine Vomiting Parasitology medicine.symptom Intensive care medicine Adverse effect business Sida |
| Zdroj: | Tropical Medicine & International Health. 14:1329-1337 |
| ISSN: | 1360-2276 |
| DOI: | 10.1111/j.1365-3156.2009.02375.x |
| Popis: | OBJECTIVE To determine the frequency and manifestations of adverse events associated with recommended first-line anti-TB drugs in children. METHOD Literature review. RESULTS Overall, children tolerate anti-TB drugs very well when using currently recommended dosages. Serious adverse events are rare and even mild symptoms such as nausea or vomiting are uncommon. There are occasional case reports of severe hepatotoxicity. CONCLUSIONS Surveillance and reporting of adverse events will need to be improved when recommended dosages of the main first-line anti-TB therapy for children are increased. Co-morbidities such as HIV infection and severe malnutrition may affect the incidence and complicate the management of possible adverse events to anti-TB therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text