Rectal Carcinoma Treated with Short-Term Preoperative Radiotherapy followed by Abdominoperineal Resection

Autor:	M. Eeftinck Schattenkerk, M.G. van der Vaart, W.C. van der Zwet, E.H. Eddes, Jan Willem Arends
Rok vydání:	2006
Předmět:	Oncology medicine.medical_specialty Preoperative radiotherapy business.industry Abdominoperineal resection Gastroenterology Rectum Total mesorectal excision medicine.anatomical_structure Internal medicine Rectal carcinoma Medicine Surgery sense organs Radiology business
Zdroj:	Digestive Surgery. 23:173-178
ISSN:	1421-9883 0253-4886
DOI:	10.1159/000094552
Popis:	Background: Treatment of choice for rectal carcinoma is short-term preoperative radiotherapy (5 × 5 Gy) followed by a total mesorectal excision (TME) of the rectum. This treatment has led to a reduction in local recurrence 2 years after surgery from 8.2 to 2.4%. Side effects of this treatment seem to be marginal and of no consequence. After introduction of short-term preoperative radiotherapy we noticed a rise in the postoperative presacral abscess formation which is difficult to treat and results in readmissions and prolonged hospital stay. Research was needed to investigate whether short-term preoperative radiotherapy can be held accountable for the presumed rise in presacral abscess formation in the treatment of rectal carcinoma. Methods: A retrospective study was performed over the period January 2000–October 2004. Two groups were formed. Group 1 existed of 30 patients who underwent a TME of the rectum without short-term preoperative radiotherapy. Group two existed of 35 patients who underwent a TME of the rectum with short-term preoperative radiotherapy. Results: Statistical analysis showed a significant increase in presacral abscess formation (13 vs. 40%) after introduction of short-term preoperative radiotherapy. Radiotherapy proved to be an important risk factor. Reduction in incidence of local recurrence was not evident. Conclusion: We found a significant increase in presacral abscess formation strongly suggestive due to the introduction of short-term preoperative radiotherapy in the treatment of rectal carcinoma. We noticed no reduction in incidence of local recurrence. We advocate that additional research is needed in order to formulate extra patient selection criteria for the use of preoperative radiotherapy in the treatment of rectal cancer.
Databáze:	OpenAIRE
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