One-Pot Synthesis of Functionalized 3-(Trifluoromethyl)phenols by [3+3] Cyclization of 1,3-Bis(silyl enol ethers) with α,β-Unsaturated Trifluoromethyl Ketones

Autor:	Thomas Pundt, Renske Klassen, T. H. Tam Dang, Peter Langer, Martin Köckerling, Helmut Reinke, Constantin Mamat
Rok vydání:	2008
Předmět:	chemistry.chemical_compound Trifluoromethyl Silylation chemistry Organic Chemistry One-pot synthesis Organic chemistry Regioselectivity Domino process Phenols Physical and Theoretical Chemistry Enol
Zdroj:	European Journal of Organic Chemistry. 2008:492-502
ISSN:	1099-0690 1434-193X
Popis:	Functionalized 3-(trifluoromethyl)phenols were prepared by formal [3+3] cyclization of 1,3-bis(silyl enol ethers) with readily available open-chained and cyclic α,β-unsaturated trifluoromethyl ketones. The reaction of 3,4-dihydro-5-(trifluoroacetyl)-2H-pyran with 1,3-bis(silyl enol ethers) resulted in a domino process to give new functionalized dihydropyrans. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Databáze:	OpenAIRE
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