| Popis: |
ObjectivesThe aim of this meta-analysis was to answer the following question: “Which are the different concentrations of Opiorphins biomarker in orofacial conditions compared to control?”.Materials and MethodsTwo reviewers searched for observational studies that evaluate the effect of Opiorphin in orofacial conditions, published on seven main databases and three from grey-literature.ResultsOf the 443 articles obtained, 08 met the inclusion criteria for quantitative analyses. Relative percentage showed mean 24.1% more opiorphin concentration in Chronic Conditions (Burning Mouth Syndrome, Oral Potentially Malignant and Temporomandibular Disorder) than controls; 33.2% more opiorphin in sustained pain (Symptomatic Irreversible Pulpitis, Symptomatic Apical Periodontitis, Painful Oral Soft-tissue Conditions); and 21.7% more opiorphin after stimuli (Corneal Foreign Body, Capsaicin). Meta-analysis found that chronic group showed 0.62 ng/ml [0.02, 1.22] more absolute concentration of opiorphin in saliva than controls. Sustained group showed 2.24 ng/ml [0.34, 4.14] more absolute concentration of opiorphin. Stimuled group showed 0.43 ng/ml [0.00, 0.85] more absolute concentration of opiorphin after stimulus. No difference in opiorphin were founded after Local Anesthesia before Tooth Extraction and Apicectomy.ConclusionsBased on the available evidence, in general, a statistically higher level of opiorphin was founded in orofacial conditions. Clinical Relevance: Salivary opiorphin levels are elevated in chronic, sustained and acute pain conditions, reflecting a physiological homeostatic adaptative response to different conditions such as fear, stress or pain. Salivary opiorphin might therefore be used as a valuable biomarker in several oral conditions. |
