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Calcium alginate microspheres embedded with silver nanoparticles were prepared by dripping mixed solution of sodium alginate and silver nanoparticles, which were synthesized by reduction of silver nitrate (AgNO3) with sodium alginate as stabilizing agent and sodium borohydride as chemical reducing agent, into a crosslinking bath of calcium chloride solution. The concentration of sodium alginate and sodium borohydride used in synthesis step were found to have effect on the formation and growth of the silver nanoparticles as revealed by UV-visible spectroscopy. The TEM image indicated that uniform silver nanoparticles with particle size range from 20 to 60 nm are fabricated. The XRD spectrums showed that the silver nanoparticles embedded in calcium alginate microspheres exhibit crystalline state. The EDS showed that the higher the ration of AgNO3, the more silver nanoparticles embedded in calcium alginate microspheres. Moreover, X-ray images showed the calcium alginate microspheres embedded with silver nanoparticles exhibited better radiopaque properties than the pure calcium alginate microspheres and the microspheres with higher concentration of AgNO3 solution show sharper X-ray image. All the above facts indicated that these calcium alginate microspheres embedded with silver nanoparticles could therefore be used in embolization. |
