The effect of Nesfatin-1 on food intake in neonatal chicks: role of CRF1 /CRF2 and H1/ H3 receptors
| Autor: | Morteza Zendehdel, Vahab Babapour, Hooman Heidarzadeh, Hasan Gilanpour |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Thioperamide General Veterinary Chemistry medicine.drug_class Histaminergic General Medicine Histamine H1 receptor Receptor antagonist Histidine decarboxylase 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology Histamine H2 receptor Internal medicine medicine Histamine H3 receptor hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Histamine medicine.drug |
| Zdroj: | Veterinary Research Communications. 42:39-47 |
| ISSN: | 1573-7446 0165-7380 |
| DOI: | 10.1007/s11259-017-9706-9 |
| Popis: | The present study was designed to determine the effect of central injection of Nesfatin-1 and corticotropin and histaminergic systems on food intake in neonatal meat-type chicks. In this study, 7 experiments were designed, each with 4 treatment groups. In experiment 1, four groups of chicks received the ICV injection of (A) phosphate-buffered saline (PBS), (B) Nesfatin-1 (10 ng), (C) Nesfatin-1 (20 ng) and (D) Nesfatin-1 (40 ng). In experiment 2, (A) PBS, (B) Astressin-B (CRF1/CRF2 receptors antagonist; 30 µg), (C) Nesfatin-1 (40 ng) and (D) Nesfatin-1 + Astressin-B were injected. In experiments 3–6, chicken received ICV injection of the Astressin2-B (CRF2 receptor antagonist; 30 µg), α-FMH (alpha fluoromethyl histidine; as inhibitor of histidine decarboxylase, 250 nmol), Chlorpheniramine (histamine H1 receptors antagonist, 300 nmol), Famotidine (histamine H2 receptors antagonist, 82 nmol) and Thioperamide (histamine H3 receptors antagonist, 300 nmol) instead of the Astressin-B. Then the cumulative food intake measured until 120 min post-injection. According to the results, ICV injection of Nesfatin-1 dose dependently decreased food intake in neonatal chicks (P |
| Databáze: | OpenAIRE |
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